Researcher Database - NAKAGAWA KIMIE | Kobe Gakuin University

NAKAGAWA KIMIE

Department / Course

Kobe Gakuin University The Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences

Job Professor

Book and thesis
2025/04	Papers	Divergent roles of 25-hydroxyvitamin D3 and 1α,25-dihydroxyvitamin D3 in neural fate determination: A CYP27B1-dependent neuron formation and VDR-dependent astrocyte development Biochemical and Biophysical Research Communications 755,pp.151547-151547
2024/04/02	Papers	Vitamin K converting enzyme UBIAD1 plays an important role in osteogenesis and chondrogenesis in mice. Biochemical and biophysical research communications 702,pp.149635-149635
2023	Papers	Vitamin K Converting Enzyme UBIAD1 Promotes the Proliferation and Differentiation of Mouse Chondrogenic ATDC5 Cells BPB Reports,pp.176-182
2022/09	Papers	Characterization of Astrocytes in the Minocycline-Administered Mouse Photothrombotic Ischemic Stroke Model. Neurochemical research 47 (9),pp.2839-2855
2022	Papers	Vitamin D Status in Japanese Young Women in 2016-2017 and 2020: Seasonal Variation and the Effect of Lifestyle Including Changes Caused by the COVID-19 Pandemic. Journal of nutritional science and vitaminology 68 (3),pp.172-180
2021/05	Papers	Concise Preparation and Biological Evaluations of 9-cis-Retinoic Acid Analogues Having an Aromatic Ring HETEROCYCLES,pp.267-267
2021/04/15	Papers	Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by Cyp24a1 and Cyp3a using Cyp24a1 knockout rats generated by CRISPR/Cas9 system. The Journal of biological chemistry 296,pp.100668-100668
2020/11	Papers	Induced mRNA expression of matrix metalloproteinases Mmp-3, Mmp-12, and Mmp-13 in the infarct cerebral cortex of photothrombosis model mice NEUROSCIENCE LETTERS 739,pp.135406-135406
2020/06	Papers	デキサメタゾン誘導性の胸腺退縮における未熟胸腺T細胞の分極化 The Journal of Toxicological Sciences 45 (Suppl.),pp.S79-S79
2020/04	Papers	Induced Prostanoid Synthesis Regulates the Balance between Th1-and Th2-Producing Inflammatory Cytokines in the Thymus of Diet-Restricted Mice BIOLOGICAL & PHARMACEUTICAL BULLETIN 43 (4),pp.649-662
2020/03	Papers	Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions SCIENTIFIC REPORTS 10 (1),pp.5677-5677
2019/04	Papers	UBIAD1 Plays an Essential Role in the Survival of Pancreatic Acinar Cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20 (8)
2019/01	Papers	Generation of 1,25-dihydroxyvitamin D-3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D-3 rescued their rachitic phenotypes JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 185,pp.71-79
2018/10	Papers	Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice PLOS ONE 13 (10),pp.e0199856
2018/08	Papers	Synthesis of novel fluorescent probes to elucidate vitamin K binding protein ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256
2018/02	Papers	Expression of tissue inhibitor of metalloproteinases and matrix metalloproteinases in the ischemic brain of photothrombosis model mice NEUROREPORT 29 (3),pp.174-180
2017/07	Papers	Determination of Menadione by Liquid Chromatography-Tandem Mass Spectrometry Using Pseudo Multiple Reaction Monitoring ANALYTICAL SCIENCES 33 (7),pp.863-867
2017/01	Papers	Nongenomic effects of 1 alpha,25-dihydroxyvitamin D-3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 483 (1),pp.359-365
2015/09	Papers	Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells JOURNAL OF MEDICINAL CHEMISTRY 58 (17),pp.7088-7092
2015/05	Papers	YY1 positively regulates human UBIAD1 expression BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 460 (2),pp.238-244
2015/04	Papers	Functional Characterization of the Vitamin K-2 Biosynthetic Enzyme UBIAD1 PLOS ONE 10 (4),pp.e0125737
2014/08	Papers	Vitamin K-2 Biosynthetic Enzyme, UBIAD1 Is Essential for Embryonic Development of Mice PLOS ONE 9 (8),pp.e104078
2014/02	Papers	Effect of Dietary Calcium and Sodium on Blood Pressure and Its Related Gene Expression in Cyp27b1 Knockout Mice. JOURNAL OF BONE AND MINERAL RESEARCH 29,pp.S254-S255
2014/02	Papers	Liver-Specific gamma-Glutamyl Carboxylase-Deficient Mice Display Bleeding Diathesis and Short Life Span PLOS ONE 9 (2),pp.e88643
2014/02	Papers	Menaquinone-4 (Vitamin K-2) in Bone Originates from Menadione (Vitamin K-3) Released from Oral Phylloquinone (Vitamin K-1) During Intestinal Absorption. JOURNAL OF BONE AND MINERAL RESEARCH 29,pp.S250-S250
2013/12	Papers	Biological Significance and Metabolic Activation of Vitamin K YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN,pp.1337-1341
2013/11	Papers	Menadione (Vitamin K-3) Is a Catabolic Product of Oral Phylloquinone (Vitamin K-1) in the Intestine and a Circulating Precursor of Tissue Menaquinone-4 (Vitamin K-2) in Rats JOURNAL OF BIOLOGICAL CHEMISTRY 288 (46),pp.33071-33080
2013/04	Papers	GENE STRUCTURE ANALYSIS OF A NOVEL HUMAN MENAQUINONE-4 BIOSYNTHETIC ENZYME UBIAD1 THAT REGULATES OSTEOBLAST FUNCTION OSTEOPOROSIS INTERNATIONAL 24,pp.S242-S242
2013/02	Papers	Accumulation of Menaqunone-4 in the Bones of Mice Orally Given K Vitamers and Its Biological Activity in Osteoblasts. JOURNAL OF BONE AND MINERAL RESEARCH 28
2012/08	Papers	Structure-Activity Relationship of Novel Vitamin K Analogues as Steroid and Xenobiotic Receptor (SXR) Agonists YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN,pp.881-886
2012/04	Papers	New Development of Vitamin K Research: Identification of Human Menaquinone-4 Biosynthetic Enzyme JOURNAL OF FOOD AND DRUG ANALYSIS 20,pp.371-375
2012/02	Papers	Structure-Activity Relationship of Novel Menaquinone-4 Analogues: Modification of the Side Chain Affects their Biological Activities JOURNAL OF MEDICINAL CHEMISTRY 55 (4),pp.1553-1558
2011/07	Papers	Synthesis of New Vitamin K Analogues as Steroid and Xenobiotic Receptor (SXR) Agonists: Insights into the Biological Role of the Side Chain Part of Vitamin K JOURNAL OF MEDICINAL CHEMISTRY 54 (13),pp.4918-4922
2011/07	Papers	ビタミンDおよびビタミンK 骨代謝に関する最近の話題ビタミンK2(Menaquinone-4)の生合成とその生物学的意義(Biosynthesis of Vitamin K2 (Menaquinone-4) and Its Biological Significance) 日本骨代謝学会学術集会プログラム抄録集 29回,pp.86-86
2011/06	Papers	Inhibitory Effect of 1 alpha-Hydroxyvitamin D-3 on N-nitrosobis (2-oxopropyl)Amine-induced Cholangiocarcinogenesis in Syrian Hamsters ACTA MEDICA OKAYAMA 65 (3),pp.193-197
2011/06	Papers	Synthesis of Novel Vitamin K-2 Analogues with Modification at the omega-Terminal Position and Their Biological Evaluation as Potent Steroid and Xenobiotic Receptor (SXR) Agonists JOURNAL OF MEDICINAL CHEMISTRY 54 (12),pp.4269-4273
2011/05	Papers	Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity BIOORGANIC & MEDICINAL CHEMISTRY 19 (9),pp.2939-2949
2011	Papers	Evaluation of the Biological Action Mechanism of Vitamin K Homologues with Chemical Techniques ビタミン,pp.271-279
2010/12	Papers	New Developments in Research on Vitamin K Biosynthesis JOURNAL OF HEALTH SCIENCE 56 (6),pp.623-631
2010/12	Papers	Role for vitamin D receptor in the neuronal control of the hematopoietic stem cell niche BLOOD 116 (25),pp.5528-5535
2010/11	Papers	Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme NATURE 468 (7320),pp.117-+
2010/08	Papers	Efficient synthesis and biological evaluation of demethyl geranylgeranoic acid derivatives BIOORGANIC & MEDICINAL CHEMISTRY 18 (16),pp.5795-5806
2010/05	Papers	Structure-activity relationships in the conversion of vitamin K analogues into menaquinone-4. Substrates essential to the synthesis of menaquinone-4 in cultured human cell lines BIOORGANIC & MEDICINAL CHEMISTRY 18 (9),pp.3116-3124
2010/03	Papers	Synthesis and Biological Evaluation of 9Z-Retinoic Acid Analogs Having 2-Substituted Benzo[b]furan CHEMICAL & PHARMACEUTICAL BULLETIN 58 (3),pp.418-422
2010/02	Papers	Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients KIDNEY INTERNATIONAL 77 (3),pp.232-238
2009/12	Papers	[In vivo metabolism of vitamin K: in relation to the conversion of vitamin K1 to MK-4]. Clinical calcium,pp.1779-1787
2008/09	Papers	Conversion of Vitamin K Analogues to Menaquinone-4 in Osteoblastic Cells. JOURNAL OF BONE AND MINERAL RESEARCH 23,pp.S389-S389
2008/09	Papers	Preparation and biological evaluation of 5-substituted retinoic acids BIOORGANIC & MEDICINAL CHEMISTRY 16 (18),pp.8471-8481
2008/09	Papers	Synthesis and development of biologically active fluorescent-labeled vitamin K analogues and monitoring of their subcellular distribution TETRAHEDRON 64 (37),pp.8789-8796
2008/04	Papers	Conversion of phylloquinone (vitamin K-1) into menaquinone-4 (vitamin K-2) in mice JOURNAL OF BIOLOGICAL CHEMISTRY 283 (17),pp.11270-11279
2008/03	Papers	Design and synthesis of biologically active analogues of vitamin K-2: Evaluation of their biological activities with cultured human cell lines BIOORGANIC & MEDICINAL CHEMISTRY 16 (6),pp.3108-3117
2007/09	Papers	Biosynthesis of menaquinone-4 (Vitamin k2) from phylloquinone (Vitamin k1) and menadione (Vitamin k3) in bone JOURNAL OF BONE AND MINERAL RESEARCH 22,pp.S264-S264
2007/09	Papers	Preparation and biological activities of heteroarotinoids LETTERS IN DRUG DESIGN & DISCOVERY 4 (6),pp.442-445
2007/09	Papers	Synthesis and biological evaluation of vitamin k(2) metabolites JOURNAL OF BONE AND MINERAL RESEARCH 22,pp.S295-S295
2007/09	Papers	Synthesis of gamma-hydroxybutenolides applying crossed aldol condensation in the presence of a bulky lewis acid and their anti-tumor activity CHEMICAL & PHARMACEUTICAL BULLETIN 55 (9),pp.1365-1370
2007/08	Papers	転移性肺癌における新規ビタミンD3アナログの抗癌作用(Anticancer Effects of the Novel Vitamin D3 Analogs in Metastatic Lung Carcinoma) 日本癌学会総会記事 66回,pp.508-508
2007/06	Papers	Catalytic asymmetric synthesis and anticancer effects of the novel non-calcemic analog of vitamin D, 2 alpha-fluoro-19-nor-22-oxa-1 alpha, 25-dihydroxyvitamin D-3 in metastatic lung carcinoma JOURNAL OF FLUORINE CHEMISTRY 128 (6),pp.654-667
2007/03	Papers	Efficient sythesis and biological evaluation of omega-oxygenated analogues of vitamin K-2: Study of modification and structure-activity relationship of vitamin K-2 metabolites BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17 (6),pp.1622-1625
2007/02	Papers	A functional single nucleotide polymorphism in the vitamin-K-dependent gamma-glutamyl carboxylase gene (Arg325Gln) is associated with bone mineral density in elderly Japanese women BONE 40 (2),pp.451-456
2006/11	Papers	Biological activities of 2 alpha-substituted analogues of 1 alpha,25-dihydroxyvitamin D-3 in transcriptional regulation and human promyelocytic leukemia (HL-60) cell proliferation and differentiation BIOLOGICAL & PHARMACEUTICAL BULLETIN 29 (11),pp.2246-2250
2006/10	Papers	Comparative uptake, metabolism, and utilization of menaquinone-4 and phylloquinone in human cultured cell lines BIOORGANIC & MEDICINAL CHEMISTRY 14 (19),pp.6601-6607
2006/09	Papers	Antitumoral activity of 13-demethyl or 13-substituted analogues of all-trans retinoic acid and 9-cis retinoic acid in the human myeloid leukemia cell line HL-60 BIOLOGICAL & PHARMACEUTICAL BULLETIN 29 (9),pp.1803-1809
2006/09	Papers	Development of a biologically active fluorescent-labeled vitamin K and monitoring of the subcellular distribution in cells. JOURNAL OF BONE AND MINERAL RESEARCH 21,pp.S387-S387
2006/07	Papers	[Effect of vitamin D on the nervous system and the skeletal muscle]. Clinical calcium,pp.1182-1187
2006/03	Papers	Inhibitory effect of long term 1 alpha-hydroxyvitamin D3 administration on Helicobacter pylori infection JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 38 (2),pp.103-106
2005/11	Papers	Biological activities of retinoidal gamma-hydroxybutenolides in cancer cell apoptosis and differentiation BIOORGANIC & MEDICINAL CHEMISTRY 13 (21),pp.6002-6008
2005/09	Papers	Vitamin K-dependent gamma-glutamyl carboxylase activity of vitamin K compounds in liver and bone. JOURNAL OF BONE AND MINERAL RESEARCH 20 (9),pp.S137-S137
2005/06	Papers	22-oxa-1 alpha,25-dihydroxyvitamin D-3 inhibits metastasis and angiogenesis in lung cancer CARCINOGENESIS 26 (6),pp.1044-1054
2005/06	Papers	Tissue-type specific anti-cancer effects and vitamin K-dependent gamma-glutamyl carboxylase activity of vitamin K compounds BONE 36,pp.S221-S221
2005/02	Papers	1 alpha,25-Dihydroxyvitamin D-3 is a preventive factor in the metastasis of lung cancer CARCINOGENESIS 26 (2),pp.429-440
2004/07	Papers	Preparation and biological activity of 13-substituted retinoic acids BIOORGANIC & MEDICINAL CHEMISTRY 12 (14),pp.3931-3942
2004/05	Papers	Metastatic growth of lung cancer cells is extremely reduced in vitamin D receptor knockout mice JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 89-90 (1-5),pp.545-547
2003/09	Papers	The development of vitamin D analogs as a therapeutic agent SEIKAGAKU,pp.1233-1238
2003/06	Papers	Metabolism of 26,26,26,27,27,27-F-6-1 alpha,25-dihydroxyvitamin D-3 by CYP24: species-based difference between humans and rats BIOCHEMICAL PHARMACOLOGY 65 (12),pp.1957-1965
2002/09	Papers	Molecular analysis of the vitamin D receptor interactions with highly potent vitamin D analogues using site-directed mutagenesis. JOURNAL OF BONE AND MINERAL RESEARCH 17,pp.S395-S395
2002/06	Papers	2-Methyl analogues of 1 alpha 25-dihydroxyvitamin D-3, the potent inducers of cell differentiation and apoptosis: synthesis and biological evaluation ANTI-CANCER DRUGS 13 (5),pp.A10-A10
2002/05	Papers	[Novel vitamin d analogues with selective biological activities]. Clinical calcium,pp.645-652
2002	Papers	1 alpha,25-Dihydroxyvitamin D, and menaqunone-4 respectively induce cell differentiation and apoptosis via induction of G0/G1 arrest in human promyelocytic leukemia HL-60 cells INTERNATIONAL JOURNAL OF CANCER,pp.346-346
2002	Papers	Tumor growth and metastasis of lung cancer cells are extremely reduced in vitamin D receptor knockout mice INTERNATIONAL JOURNAL OF CANCER,pp.161-161
2002	Papers	Analysis of Molecular Mechanism of Cancer Cell Differentiation and Apoptosis Induced by Vitamin D3 Analogs on the Basis of Molecular Recognition of Vitamin D Receptor Ligand Binding Domain. 薬学雑誌,pp.781-791
2001/09	Papers	Molecular mechanism of differentiation and apoptosis-inducing actions of A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D-3 in human promyelocytic leukemia (HL-60) cells. JOURNAL OF BONE AND MINERAL RESEARCH 16,pp.S555-S555
2001/05	Papers	Molecular mechanism of cell differentiation and apoptosis induced by A-ring analogues of 1alpha,25-dihydroxyvitamin D-3 BONE 28 (5),pp.S98-S98
2001/03	Papers	Systematic studies on synthesis, structural elucidation, and biological evaluation of A-ring diastereomers of 2-methyl-1 alpha,25-dihydroxyvitamin D-3 and 20-epi-2-methyl-1 alpha,25-dihydroxyvitamin D-3 STEROIDS 66 (3-5),pp.277-285
2001	Books	Biological activity of vitamin D analogs
2001	Papers	Asymmetric catalytic ene-cyclization approach to 2-fluoro- 19-nor-1,25-dihydroxyvitamin D3 A-ring analog with significant transactivation activity Chirality 13 (7),pp.366-371
2000/09	Papers	Structure-specific and concentration-dependent stimulation of apoptosis by A-ring stereoisomers of 1 alpha,25-dihydroxyvitamin D-3 in HL-60 cells. JOURNAL OF BONE AND MINERAL RESEARCH 15,pp.S575-S575
2000/05	Papers	Biological activities of 19-nor-1 alpha,25-dihydroxyvitamin D3 analogs singly dehydroxylated at the C-1 or C-3 position of the A-ring CURRENT PHARMACEUTICAL DESIGN 6 (7),pp.791-801
2000/05	Papers	Biological activities of 19-nor-1 alpha,25-dihydroxyvitamin D3 analogs singly dehydroxylated at the C-1 or C-3 position of the A-ring CURRENT PHARMACEUTICAL DESIGN 6 (7),pp.791-801
2000/02	Papers	Absorption of calcium, magnesium, phosphorus, iron, and zinc in growing male rats fed diets containing either phytate-free soybean protein or soybean protein isolate or casein JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 46 (1),pp.34-41
2000/02	Papers	ラットにおけるカルシウム,マグネシウム,リン,鉄,亜鉛吸収率に及ぼす脱フィチン酸大豆タンパク質の影響 Journal of Nutritional Science and Vitaminology 46 (1),pp.34-41
2000/01	Papers	In vitro biological activities of a series of 2 beta-substituted analogues of 1 alpha,25-dihydroxyvitamin D-3 BIOLOGICAL & PHARMACEUTICAL BULLETIN 23 (1),pp.66-71
1999/09	Papers	Structure-specific control of apoptosis by novel 2-methyl-A-ring stereoisomers of l alpha,25-dihydroxyvitamin D-3, and 20-epi-1 alpha,25-dihydroxyvitamin D-3 in HL-60 cells. JOURNAL OF BONE AND MINERAL RESEARCH 14,pp.S214-S214